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Check Closely (one)pentobarbital will decrease the level or outcome of levamlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the extent or outcome of flurbiprofen by impacting hepatic enzyme CYP2C9/10 metabolism. Minor/Importance Unfamiliar.pentobarbital will lessen the extent or outcome of ramelteon by in